URL details: www.genomemedicine.com/content/8/1/11
URL title:
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens | Genome Medicine | Full Text
URL description:
Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tumor-specific mutant peptides (neoantigens) can elicit anti-tumor T cell immunity are needed to improve predictions of checkpoint therapy response and to identify targets for vaccines and adoptive T cell therapies. Here, we present a flexible,
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