URL details: doi.org/10.1038/s41467-020-18233-x
URL title:
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease | Nature Communications
URL description:
COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the viral polyprotein, therefore recognized as an attractive drug target. Here we show that a clinically approved anti-HCV drug, Boceprevir, and a pre-clinical inhibitor against feline infectious peritonitis (corona) virus (FIPV), GC376, both efficaciously inhibit SARS-CoV-2 in Vero cells by targeting Mpro
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